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- Title
Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2-T1R3 receptor
- Authors
Temussi, Piero Andrea
- Abstract
Sweet tasting proteins interact with the same receptor that binds small molecular weight sweeteners, the T1R2–T1R3 G-protein coupled receptor, but the key groups on the protein surface responsible for the biological activity have not yet been identified. I propose that sweet proteins, contrary to small ligands, do not bind to the ‘glutamate-like’ pocket but stabilize the free form II of the T1R2–T1R3 receptor by attachment to a secondary binding site. Docking of brazzein, monellin and thaumatin with a model of the T1R2–T1R3 sweet taste receptor shows that the most likely complexes can indeed stabilize the active form of the receptor.
- Subjects
PROTEINS; LIGANDS (Biochemistry)
- Publication
FEBS Letters, 2002, Vol 526, Issue 1-3, p1
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)03155-1