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- Title
Synthesis of Axially Chiral CF<sub>3</sub>‐Substituted 2‐Arylpyrroles by Sequential Phosphine‐Catalyzed Asymmetric [3+2] Annulation and Oxidative Central‐to‐Axial Chirality Transfer.
- Authors
Xiang Alvin Tan, Chuan; Li, Rui; Zhang, Fuhao; Dai, Lei; Ullah, Nisar; Lu, Yixin
- Abstract
A sequential phosphine‐catalyzed asymmetric [3+2] annulation of aldimines with allenoates and oxidative central‐to‐axial chirality transfer strategy has been developed. This approach is operationally simple, allowing for rapid access to a range of axially chiral CF3‐containing 2‐arylpyrroles with high enantiomeric excess. Furthermore, an atroposelective synthesis of esaxerenone is presented, illustrating the practical potential of the reported method.
- Subjects
ANNULATION; CHIRALITY; ALDIMINES; CHIRALITY element
- Publication
Angewandte Chemie, 2022, Vol 134, Issue 47, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202209494