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- Title
Asymmetric Double Hydroxycarbonylation of Alkynes to Chiral Succinic Acids Enabled by Palladium Relay Catalysis.
- Authors
Ji, Xiaolei; Shen, Chaoren; Tian, Xinxin; Zhang, Hongru; Ren, Xinyi; Dong, Kaiwu
- Abstract
A Pd‐catalyzed asymmetric double hydroxycarbonylation of terminal alkynes was developed by using relay catalysis, providing a highly efficient route to chiral succinic acids (41 examples, 76–94 %, 94–99 % ee). Key to success was the combinatorial use of a Pd precursor with two distinct phosphine ligands in one pot. The synthetic utilities of this protocol were showcased in the facile synthesis of key intermediates for chiral pharmaceuticals.
- Subjects
SUCCINIC acid; PALLADIUM; ALKYNES; CATALYSIS; PALLADIUM catalysts
- Publication
Angewandte Chemie, 2022, Vol 134, Issue 29, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202204156