We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
FİBROMİYALJİ SENDROMU OLAN HASTALARDA miRNA PROFİLLERİNİN ROLÜ VE ÖNEMİ.
- Authors
RASULOVA, Khayala; PEHLİVAN, Melek; DİLEK, Banu; KIZILDAĞ, Sefa
- Abstract
Fibromyalgia syndrome (FMS) is a chronic musculoskeletal pain disorder associated with other symptoms. It is mainly characterized by pain, fatigue, and sleep disturbance. Many other genetic, immunological, and hormonal factors play an important role in the etiology of fibromyalgia. This pathological condition affects approximately 3-10% of the population. The incidence of the disease is more often in women. Women show more severe symptoms and lower pain threshold than men. Therefore, most of the research has focused on female subjects. MicroRNAs (miRNAs) regulate at least 30% of human genes. In recent years, miRNAs have been identified as important modulators of gene expression in disease processes and physiological pathways. However, each microRNA may be responsible for regulation of hundreds of genes. miRNAs inhibit the gene expression after transcription through inhibition of translation or degradation of target messenger RNA. The purpose of this review is to discuss the role of miRNAs in FMS disease. According to the studies, some miRNA expression levels were changed in FMS patients. The presence of microRNAs in different cellular compartments and their extracellular stability make them interesting candidate biomarkers for better understanding the etiology of complex diseases such as FMS.
- Publication
Medical Journal of Suleyman Demirel University, 2021, Vol 28, Issue 3, p529
- ISSN
1300-7416
- Publication type
Article
- DOI
10.17343/sdutfd.792825