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- Title
MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication.
- Authors
Chou, Wen-Wen; Huang, Chung-Feng; Yeh, Ming-Lun; Tsai, Yi-Shan; Hsieh, Ming-Yen; Huang, Ching-I; Huang, Jee-Fu; Tsai, Pei-Chien; Hsi, Edward; Juo, Suh-Hang; Tsai, Wei-Lun; Chuang, Wan-Long; Yu, Ming-Lung; Dai, Chia-Yen
- Abstract
MicroRNAs (miRNA) have been implicated in HCV infection. The present study analyzed the effects of let-7g on HCV infection in vitro, in clinical tissue and serum samples. Here, we show that the expression of let-7g in serum and liver tissue is significantly higher in patients with sustained virologic response (SVR). We show that interferon (IFN)/ribavirin (RBV) induces let-7g expression through p38/AP-1 signaling. Overexpression of let-7g reduced HCV gene or core protein level and inhibited the HCV viral load. The let-7g and IFN/RBV have additively inhibitory effect on HCV replication. These data implicate let-7g as a new therapeutic drug to additively cooperate with IFN/RBV to repress HCV replication. Key messages:
- Subjects
MICRORNA; INTERFERONS; RIBAVIRIN; HEPATITIS C virus; VIRAL replication
- Publication
Journal of Molecular Medicine, 2016, Vol 94, Issue 3, p311
- ISSN
0946-2716
- Publication type
Article
- DOI
10.1007/s00109-015-1348-1