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- Title
Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma.
- Authors
Bozec, Alexandre; Ilie, Marius; Dassonville, Olivier; Long, Elodie; Poissonnet, Gilles; Santini, José; Chamorey, Emmanuel; Ettaiche, Marc; Chauvière, Damien; Peyrade, Frédéric; Hebert, Christophe; Benezery, Karen; Sudaka, Anne; Haudebourg, Juliette; Selva, Eric; Hofman, Paul
- Abstract
The objective of this study was to evaluate the potential detection of circulating tumor cells (CTCs) using the CellSearch (CS) Assay™ in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) and then to identify the clinical factors predictive of the presence of CTCs. The presence and number of CTCs were determined using the CS system before treatment, and in 10 healthy individuals (control group). The CS system was able to successfully identify the presence of CTCs in 8 of 49 patients (16 %) before therapy. No CTC was found in the control group. CTCs were detected before therapy in 1 of 19 patients (5 %) with N0 tumor and in 7 of 30 patients (23 %) with N1-2c tumor ( p = 0.12; Fisher's exact test). CTCs were identified in a relatively low proportion of patients with locally advanced HNSCC.
- Subjects
CANCER cell analysis; SQUAMOUS cell carcinoma; CANCER treatment; HEAD &; neck cancer treatment; CANCER patients; DIAGNOSIS
- Publication
European Archives of Oto-Rhino-Laryngology, 2013, Vol 270, Issue 10, p2745
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-013-2399-y