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- Title
Effects of Statins on Serum n-3 to n-6 Polyunsaturated Fatty Acid Ratios in Patients With Coronary Artery Disease.
- Authors
Nozue, Tsuyoshi; Yamamoto, Shingo; Tohyama, Shinichi; Fukui, Kazuki; Umezawa, Shigeo; Onishi, Yuko; Kunishima, Tomoyuki; Sato, Akira; Nozato, Toshihiro; Miyake, Shogo; Takeyama, Youichi; Morino, Yoshihiro; Yamauchi, Takao; Muramatsu, Toshiya; Hibi, Kiyoshi; Michishita, Ichiro
- Abstract
Background: A low n-3 to n-6 polyunsaturated fatty acids (PUFAs) ratio is reported to be associated with cardiovascular events.However, the effects of statins on this ratio have not been fully examined. Methods: A total of 101 patients with coronary arterydisease, who were not receiving lipid-lowering therapy were randomly assigned to receive either 4 mg/day of pitavastatin or 20mg/day of pravastatin. Serum PUFA levels were measured at baseline and 8 months after treatment with statins. Results: Pitavastatinwas used to treat 51 patients and the remaining 50 patients were treated using pravastatin. A significant positive correlationwas observed between the percent change in low-density lipoprotein cholesterol and that in dihomogamma-linolenic acid(r = .376, P = .007), arachidonic acid (AA; r = .316, P = .02), eicosapentaenoic acid (EPA; r = .408, P = .003), or docosahexaenoicacid (DHA; r = .270, P = .056) in the pitavastatin group. However, these correlations were not observed in the pravastatin group.The DHA/AA ratio decreased significantly in the pitavastatin group only (from 0.96 to 0.83, P = .0002) and the DHA/AA ratio wassignificantly lower in the pitavastatin group at 8 months (0.83 vs 0.96, P = .03). The EPA/AA ratio did not show significant changesin either group. Conclusions: Pitavastatin decreased the serum DHA/AA ratio, whereas pravastatin had no effect on this ratio.Neither pitavastatin nor pravastatin had an effect on the serum EPA/AA ratio in patients with coronary artery disease.
- Subjects
STATINS (Cardiovascular agents); PHYSIOLOGICAL effects of unsaturated fatty acids; CARDIOVASCULAR diseases risk factors; CORONARY heart disease treatment; ANTILIPEMIC agents
- Publication
Journal of Cardiovascular Pharmacology & Therapeutics, 2013, Vol 18, Issue 4, p320
- ISSN
1074-2484
- Publication type
Article
- DOI
10.1177/1074248412473202