We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Unmet Challenges in Patients with Crohn's Disease.
- Authors
Scheurlen, Katharina M; Parks, Mary A; Macleod, Anne; Galandiuk, Susan
- Abstract
Patients with Crohn's disease can present with a variety of clinical manifestations; treatment strategies should focus on long-term remission and improvement of quality of life. There is no standardized process of diagnosing, predicting prognosis, and treating the disease. This narrative review was based on a literature search using PubMed, Embase, and Science Direct. Data on unmet challenges in patients with Crohn's disease were extracted from identified manuscripts. The aim was to discuss present research on standardized processes in the management of patients with Crohn's disease and to identify the unmet needs in clinical evaluation and treatment approaches. There is no consensus on standardized diagnostic, treatment, and surveillance algorithms, particularly in assessing complications of Crohn's, such as stricturing disease, intestinal cancer risk, and cutaneous manifestations. Complications and treatment failure rates of conventional, interventional, and surgical therapy place emphasis on the need for standardized treatment algorithms, particularly in the case of acute complications of the disease. Research on standardized clinical approaches, reliable biomarkers for disease diagnosis and therapy monitoring, and new treatment agents is necessary to improve therapy and reduce complications in patients with Crohn's disease.
- Subjects
CROHN'S disease; DISEASE remission; INTESTINAL cancer; INFLAMMATORY bowel diseases; SYMPTOMS; DISEASE risk factors
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 17, p5595
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12175595