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- Title
The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic.
- Authors
Licordari, Roberto; Sticchi, Alessandro; Mancuso, Filippo; Caracciolo, Alessandro; Muscoli, Saverio; Iacovelli, Fortunato; Ruggiero, Rossella; Scoccia, Alessandra; Cammalleri, Valeria; Pavani, Marco; Loffi, Marco; Scordino, Domenico; Ferro, Jayme; Rognoni, Andrea; Buono, Andrea; Nava, Stefano; Albani, Stefano; Colaiori, Iginio; Zilio, Filippo; Borghesi, Marco
- Abstract
Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 10, p2926
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11102926