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- Title
Surgical Quality, Antihypertensive Therapy, and Electrolyte Balance: A Novel Trifecta to Assess Long-Term Outcomes of Adrenal Surgery for Unilateral Primary Aldosteronism.
- Authors
Anceschi, Umberto; Mormando, Marilda; Fiori, Cristian; Zappalà, Orazio; De Concilio, Bernardino; Brassetti, Aldo; Carrara, Alessandro; Ferriero, Maria Consiglia; Tuderti, Gabriele; Misuraca, Leonardo; Bove, Alfredo Maria; Mastroianni, Riccardo; Chiefari, Alfonsina; Appetecchia, Marialuisa; Tirone, Giuseppe; Porpiglia, Francesco; Celia, Antonio; Gallucci, Michele; Simone, Giuseppe
- Abstract
Background: To propose a trifecta that summarizes endpoints and predicts their maintenance after adrenalectomy (n = 90) for unilateral primary aldosteronism (UPA). Methods: Trifecta was defined as coexistence of: ≥50% antihypertensive therapeutic intensity score reduction (∆TIS), no hypokalemia at 3 months, and no Clavien grade 2–5. Logistic regression was used to identify predictors of trifecta. Probability of clinical, biochemical, and simultaneous success according to trifecta were assessed by Kaplan–Meier. Cox regression was used to identify predictors of long-term clinical, biochemical, and simultaneous success. For all analyses, a two-sided p < 0.05 was considered significant. Results: Simultaneous success rate was 50%. On multivariable analysis, TIS was an independent predictor of trifecta achievement (HR 3.28; 95% CI 1.07–10.9; p = 0.03). At Kaplan–Meier, trifecta predicted higher success for all endpoints (each p < 0.03). On multivariable Cox analysis, adenoma size (AS) ≥6 cm and trifecta were independent predictors of biochemical (AS: HR 2.87; 95% CI 1.53–5.36; trifecta: HR 2.1; 95% CI 1.13–3.90; each p < 0.02) and simultaneous success (AS: HR 3.81; 95% CI 1.68–8.65; trifecta: HR 4.29; 95% CI 2.08–8.86; each p < 0.01), while trifecta was an independent predictor of complete clinical success (HR 2.84; 95% CI 1.45–5.58; p < 0.01). Conclusions: Trifecta and AS are independent predictors of either long-term complete clinical, biochemical, or combined success after adrenalectomy for UPA.
- Subjects
WATER-electrolyte balance (Physiology); HYPERALDOSTERONISM; TREATMENT effectiveness; LOGISTIC regression analysis; ADRENALECTOMY
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 3, p794
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11030794