We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Neuroprotective Effect of Thiopental on the Postoperative Neurological Complications in Patients Undergoing Surgical Clipping of Unruptured Intracranial Aneurysm: A Retrospective Analysis.
- Authors
Kim, Byung-Gun; Jeon, Young-Tae; Han, Jiwon; Bae, Yu Kyung; Lee, Si Un; Ryu, Jung-Hee; Koo, Chang-Hoon
- Abstract
Although thiopental improved neurological outcomes in several animal studies, there are still insufficient clinical data examining the efficacy of thiopental for patients undergoing surgical clipping of unruptured intracranial aneurysm (UIA). This study validated the effect of thiopental and investigated risk factors associated with postoperative neurological complications in patients undergoing surgical clipping of UIA. In total, 491 patients who underwent aneurysm clipping were included in this retrospective cohort study. Data regarding demographics, aneurysm characteristics, and use of thiopental were collected from electronic medical records. Propensity score matching and logistic regression analysis were used. After propensity score matching, the thiopental group showed a lower incidence of the postoperative neurological complications than non-thiopental group (5.5% vs. 17.1%, p = 0.001). In multivariate analysis, thiopental reduced the risk of postoperative neurological complications (odds ratio (OR) 0.26, 95% confidence interval (CI) 0.13 to 0.51, p < 0.001) while aneurysm size ≥ 10 mm (OR 4.48, 95% CI 1.69 to 11.87, p = 0.003), and hyperlipidemia (OR 2.24, 95% CI 1.16 to 4.32, p = 0.02) increased the risk of postoperative neurological complications. This study showed that thiopental was associated with the lower risk of neurological complications after clipping of UIA.
- Subjects
INTRACRANIAL aneurysms; SURGICAL complications; PREOPERATIVE risk factors; PROPENSITY score matching; LOGISTIC regression analysis
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 6, p1197
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10061197