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- Title
Determination of cefetamet pivoxil in human urine and serum using flow injection chemiluminescence procedure.
- Authors
Xiaodong Shao; Xin Li; Bei Liu; Zhenghua Song
- Abstract
A sensitive chemiluminescence method based on enhancing the effect of cefetamet pivoxil on the chemiluminescent reaction between luminol and dissolved oxygen in a flow injection system was proposed for the determination of cefetamet pivoxil. The increment of the chemiluminescence intensity was proportional to the concentration of cefetamet pivoxil, which yields a calibration graph that is linear over the concentration from 0.4 to 100.0 ng/mL ( r 2 = 0.991) with the detection limit of 0.1 ng/mL (3σ). At a flow rate of 2.0 mL/min complete determination of cefetamet pivoxil, including sampling and washing, could be accomplished in 40 s with the RSD of less than 0.03 ( n = 5). The proposed method was applied successfully to the determination of cefetamet pivoxil in human urine and human serum.
- Subjects
CHEMILUMINESCENCE; FLOW injection analysis; LUMINESCENCE; SERUM; URINE; ANALYTICAL chemistry
- Publication
Journal of Analytical Chemistry, 2009, Vol 64, Issue 1, p71
- ISSN
1061-9348
- Publication type
Article
- DOI
10.1134/S1061934809010146