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- Title
Cilostazol attenuates kainic acid-induced hippocampal cell death.
- Authors
Park, Young-Seop; Zhen Jin; Eun Ae Jeong; Chin-ok Yi; Jong Youl Lee; Park, In Sung; Gu Seob Roh
- Abstract
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity.
- Subjects
KAINIC acid; CELL death; PHOSPHODIESTERASES; CYCLIC adenylic acid; NEUROPROTECTIVE agents
- Publication
Korean Journal of Physiology & Pharmacology, 2018, Vol 22, Issue 1, p63
- ISSN
1226-4512
- Publication type
Article
- DOI
10.4196/kjpp.2018.22.1.63