We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Evaluation of alveolar bone hypomineralization in pediatric hypophosphatasia using orthopantomography.
- Authors
Okawa, Rena; Nakamoto, Takashi; Matayoshi, Saaya; Nakano, Kazuhiko; Kakimoto, Naoya
- Abstract
Hypophosphatasia (HPP) is a metabolic disease characterized by impaired bone mineralization and early exfoliation of primary teeth. This study was performed to develop a method for quantitatively evaluating alveolar bone hypomineralization using orthopantomographic images. Alveolar bone density was defined according to the pixel values and corrected by brightness shown by an indicator applied to the orthopantomographic device. Images of 200 healthy subjects (aged 2–15 years) were classified into five age groups. The corrected pixel values were significantly lower in the younger group than in those aged 14–15 years (2–4, 5–7, and 8–10 years versus 14–15 years: P < 0.0001, 11–13 years versus 14–15 years: P < 0.01). Orthopantomographic images of 17 patients with HPP were evaluated. The corrected pixel values of three-fourths of the patients with odonto type HPP were lower than the mean values of the healthy group. One-third of patients treated with enzyme replacement therapy showed higher corrected pixel values than the healthy group. Our results suggest that odonto type HPP without skeletal problems is occasionally accompanied by hypomineralization of alveolar bone and that alveolar bone hypomineralization in patients with severe HPP is possibly improved by enzyme replacement therapy.
- Subjects
PANORAMIC radiography; HYPOPHOSPHATASIA; ENZYME replacement therapy; BONE density; ALVEOLAR process
- Publication
Scientific Reports, 2022, Vol 12, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-022-05171-5