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Innentitelbild: Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose (Angew. Chem. 29/2020).
Published in:
Angewandte Chemie, 2020, v. 132, n. 29, p. 11770, doi. 10.1002/ange.202005824
By:
- Chow, Wing Ying;
- Norman, Brendan P.;
- Roberts, Norman B.;
- Ranganath, Lakshminarayan R.;
- Teutloff, Christian;
- Bittl, Robert;
- Duer, Melinda J.;
- Gallagher, James A.;
- Oschkinat, Hartmut
Publication type:
Article
Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose.
Published in:
Angewandte Chemie, 2020, v. 132, n. 29, p. 12035, doi. 10.1002/ange.202000618
By:
- Chow, Wing Ying;
- Norman, Brendan P.;
- Roberts, Norman B.;
- Ranganath, Lakshminarayan R.;
- Teutloff, Christian;
- Bittl, Robert;
- Duer, Melinda J.;
- Gallagher, James A.;
- Oschkinat, Hartmut
Publication type:
Article
Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6423, doi. 10.3390/ijms24076423
By:
- Loh, Hui-Yi;
- Norman, Brendan P.;
- Lai, Kok-Song;
- Cheng, Wan-Hee;
- Nik Abd. Rahman, Nik Mohd Afizan;
- Mohamed Alitheen, Noorjahan Banu;
- Osman, Mohd Azuraidi
Publication type:
Article
The Regulatory Role of MicroRNAs in Breast Cancer.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 19, p. 4940, doi. 10.3390/ijms20194940
By:
- Loh, Hui-Yi;
- Norman, Brendan P.;
- Lai, Kok-Song;
- Rahman, Nik Mohd Afizan Nik Abd.;
- Alitheen, Noorjahan Banu Mohamed;
- Osman, Mohd Azuraidi
Publication type:
Article
Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria.
Published in:
Metabolites (2218-1989), 2022, v. 12, n. 10, p. 920, doi. 10.3390/metabo12100920
By:
- Ranganath, Lakshminarayan R.;
- Hughes, Andrew T.;
- Davison, Andrew S.;
- Khedr, Milad;
- Imrich, Richard;
- Rudebeck, Mattias;
- Olsson, Birgitta;
- Norman, Brendan P.;
- Bou-Gharios, George;
- Gallagher, James A.;
- Milan, Anna M.
Publication type:
Article
Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria.
Published in:
Metabolites (2218-1989), 2022, v. 12, n. 10, p. 927, doi. 10.3390/metabo12100927
By:
- Norman, Brendan P.;
- Davison, Andrew S.;
- Hickton, Bryony;
- Ross, Gordon A.;
- Milan, Anna M.;
- Hughes, Andrew T.;
- Wilson, Peter J. M.;
- Sutherland, Hazel;
- Hughes, Juliette H.;
- Roberts, Norman B.;
- Bou-Gharios, George;
- Gallagher, James A.;
- Ranganath, Lakshminarayan R.
Publication type:
Article
Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment.
Published in:
Metabolites (2218-1989), 2022, v. 12, n. 8, p. 772, doi. 10.3390/metabo12080772
By:
- Ranganath, Lakshminarayan R.;
- Milan, Anna M.;
- Hughes, Andrew T.;
- Davison, Andrew S.;
- Khedr, Milad;
- Imrich, Richard;
- Rudebeck, Mattias;
- Olsson, Birgitta;
- Norman, Brendan P.;
- Bou-Gharios, George;
- Gallagher, James A.
Publication type:
Article
Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria.
Published in:
Metabolites (2218-1989), 2022, v. 12, n. 6, p. 477, doi. 10.3390/metabo12060477
By:
- Davison, Andrew S.;
- Norman, Brendan P.;
- Sutherland, Hazel;
- Milan, Anna M.;
- Gallagher, James A.;
- Jarvis, Jonathan C.;
- Ranganath, Lakshminarayan R.
Publication type:
Article
Increased prevalence of Parkinson's disease in alkaptonuria.
Published in:
Journal of Inherited Metabolic Disease Reports, 2023, v. 64, n. 4, p. 282, doi. 10.1002/jmd2.12367
By:
- Ranganath, Lakshminarayan;
- Khedr, Milad;
- Milan, Anna M.;
- Davison, Andrew S.;
- Norman, Brendan P.;
- Janssen, Mirian C. H.;
- Lock, Edward;
- Bou‐Gharios, George;
- Gallagher, James A.
Publication type:
Article
Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria—An approach using statistical modelling.
Published in:
Journal of Inherited Metabolic Disease Reports, 2022, v. 63, n. 1, p. 80, doi. 10.1002/jmd2.12261
By:
- Ranganath, Lakshminarayan R.;
- Milan, Anna M.;
- Hughes, Andrew T.;
- Khedr, Milad;
- Norman, Brendan P.;
- Alsbou, Mohammed;
- Imrich, Richard;
- Gornall, Matthew;
- Sireau, Nicolas;
- Gallagher, James A.;
- Jackson, Richard
Publication type:
Article
Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC-QTOF-MS.
Published in:
Journal of Inherited Metabolic Disease Reports, 2019, v. 48, n. 1, p. 67, doi. 10.1002/jmd2.12042
By:
- Davison, Andrew S.;
- Norman, Brendan P.;
- Ross, Gordon A.;
- Hughes, Andrew T.;
- Khedr, Milad;
- Milan, Anna M.;
- Gallagher, James A.;
- Ranganath, Lakshminarayan R.
Publication type:
Article
Early Onset Parkinson's Disease in a family of Moroccan origin caused by a p.A217D mutation in PINK1: a case report.
Published in:
2017
By:
- Norman, Brendan P.;
- Lubbe, Steven J.;
- Tan, Manuela;
- Warren, Naomi;
- Morris, Huw R.
Publication type:
journal article
A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.
Published in:
Clinical Chemistry, 2019, v. 65, n. 4, p. 530, doi. 10.1373/clinchem.2018.295345
By:
- Norman, Brendan P.;
- Davison, Andrew S.;
- Ross, Gordon A.;
- Milan, Anna M.;
- Hughes, Andrew T.;
- Sutherland, Hazel;
- Jarvis, Jonathan C.;
- Roberts, Norman B.;
- Gallagher, James A.;
- Ranganath, Lakshminarayan R.
Publication type:
Article
Inside Cover: Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Angew. Chem. Int. Ed. 29/2020).
Published in:
Angewandte Chemie International Edition, 2020, v. 59, n. 29, p. 11674, doi. 10.1002/anie.202005824
By:
- Chow, Wing Ying;
- Norman, Brendan P.;
- Roberts, Norman B.;
- Ranganath, Lakshminarayan R.;
- Teutloff, Christian;
- Bittl, Robert;
- Duer, Melinda J.;
- Gallagher, James A.;
- Oschkinat, Hartmut
Publication type:
Article
Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage.
Published in:
Angewandte Chemie International Edition, 2020, v. 59, n. 29, p. 11937, doi. 10.1002/anie.202000618
By:
- Chow, Wing Ying;
- Norman, Brendan P.;
- Roberts, Norman B.;
- Ranganath, Lakshminarayan R.;
- Teutloff, Christian;
- Bittl, Robert;
- Duer, Melinda J.;
- Gallagher, James A.;
- Oschkinat, Hartmut
Publication type:
Article
Nitisinone causes acquired tyrosinosis in alkaptonuria.
Published in:
Journal of Inherited Metabolic Disease, 2020, v. 43, n. 5, p. 1014, doi. 10.1002/jimd.12229
By:
- Khedr, Milad;
- Cooper, Maggie S.;
- Hughes, Andrew T.;
- Milan, Anna M.;
- Davison, Andrew S.;
- Norman, Brendan P.;
- Sutherland, Hazel;
- Jarvis, Jonathan C.;
- Fitzgerald, Richard;
- Markinson, Louise;
- Psarelli, Eftychia‐Eirini;
- Ghane, Parisa;
- Deutz, Nicolaas E. P.;
- Gallagher, James A.;
- Ranganath, Lakshminarayan R.
Publication type:
Article
Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria.
Published in:
Journal of Inherited Metabolic Disease, 2020, v. 43, n. 4, p. 737, doi. 10.1002/jimd.12181
By:
- Ranganath, Lakshminarayan R.;
- Milan, Anna M.;
- Hughes, Andrew T.;
- Khedr, Milad;
- Davison, Andrew S.;
- Shweihdi, Ella;
- Norman, Brendan P.;
- Hughes, Juliette H.;
- Bygott, Helen;
- Luangrath, Emily;
- Fitzgerald, Richard;
- Psarelli, Eftychia E.;
- Kan, Christa;
- Laan, Dinny;
- Olsson, Birgitta;
- Rudebeck, Mattias;
- Mankowitz, Louise;
- Sireau, Nicolas;
- Arnoux, Jean‐Baptiste;
- Le Quan Sang, Kim‐Hanh
Publication type:
Article
Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease—A review.
Published in:
Journal of Inherited Metabolic Disease, 2019, v. 42, n. 5, p. 776, doi. 10.1002/jimd.12152
By:
- Ranganath, Lakshminarayan R.;
- Norman, Brendan P.;
- Gallagher, James A.
Publication type:
Article
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria.
Published in:
Human Molecular Genetics, 2019, v. 28, n. 23, p. 3928, doi. 10.1093/hmg/ddz234
By:
- Hughes, Juliette H.;
- Liu, Ke;
- Plagge, Antonius;
- Wilson, Peter J.M.;
- Sutherland, Hazel;
- Norman, Brendan P;
- Hughes, Andrew T.;
- Keenan, Craig M;
- Milan, Anna M.;
- Sakai, Takao;
- Ranganath, Lakshminarayan R.;
- Gallagher, James A.;
- Bou-Gharios, George
Publication type:
Article

Found: 19