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- Title
The Tokyo Twin Cohort Project: overview and initial findings.
- Authors
Ando, Juko; Nonaka, Koichi; Ozaki, Koken; Sato, Naho; Fujisawa, Keiko K.; Suzuki, Kunitake; Yamagata, Shinji; Takahashi, Yusuke; Nakajima, Ryoko; Kato, Noriko; Ooki, Syuichi
- Abstract
The Tokyo Twin Cohort Project (ToTCoP) is a large-scale longitudinal study of 5 years based on 1619 pairs of infant twins reared together. The purpose of the study is to construct a population-based twin registry in Japan and to investigate human growth and development and twin themselves. It covers behavioral, neurological, physical and environmental variables measured by questionnaire, home visiting and brain imaging technology. The full registry contains over 47,000 multiple births collected from the Basic Resident Register, and the targeted population is 3070 probable twins of 0 to 2 years old. Preliminary analysis of the entry questionnaire data showed no serious sampling biases. Descriptive statistics of parental characteristics (parental age, gestation age, parity and placentation, maternal weight, parenting stress) and children's characteristics (body size at birth, 4 and 10 months of age, milk consumption, and sleeping and social behavior) and their correlations, genetic and environmental contributions and correlations are reported.
- Subjects
JAPAN; TWINS; PUBLIC health records; RECORDING &; registration; GENOTYPE-environment interaction; NATURE &; nurture; DEVELOPMENTAL biology; GENETICS; EPIDEMIOLOGICAL research; LONGITUDINAL method; PILOT projects; ACQUISITION of data; PATIENT selection
- Publication
Twin Research & Human Genetics, 2006, Vol 9, Issue 6, p817
- ISSN
1832-4274
- Publication type
journal article
- DOI
10.1375/twin.9.6.817