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- Title
Temporary disruption of fear-potentiated startle following PKM? inhibition in the amygdala.
- Authors
Parsons, Ryan G.; Davis, Michael
- Abstract
We examined whether protein kinase M zeta (PKM?) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKM? blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effect when rats were tested with longer retention intervals. These results suggest that PKM? inhibition does not erase memory, but temporarily disrupts expression of memory.
- Subjects
PROTEIN kinases; AMYGDALOID body; RATS; DRUG synergism; SALINE solutions; ACETOPHENONE
- Publication
Nature Neuroscience, 2011, Vol 14, Issue 3, p295
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2745