We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Intestinal colonization in Polish infants: From newborns till 18-month-old children.
- Authors
Stencel-Gabriel, Krystyna; Gabriel, Iwona; Wiczkowski, Andrzej; Olejek, Anita
- Abstract
Introduction Human intestinal colonization is a dynamic process that is nowadays redefining due to hygienic changes in the Polish population. Aim To analyze the development of the intestinal flora from newborns till 18-month-old infants in Poland. Material and methods 171 newborns were enrolled. We collected fecal samples at 5 timepoints (1st stool, at 3, 6, 12, 18 months). At each visit, the questionnaire concerning breastfeeding, antibiotics, probiotics was obtained including atopy family history at the first visit. Results The count of staphylococci, enterococci, lactobacilli decreased (mean 0 months vs. 18 months: 3.08 × 10 7 CFU/g vs. 6.35 × 10 6 CFU/g; 1.85 × 10 10 CFU/g vs. 9.26 × 10 7 CFU/g; 3.3 × 10 11 CFU/g vs. 3.11 × 10 7 CFU/g) and Clostridium difficile and Gram-negative bacilli increased (6.2 × 10 4 CFU/g vs. 1.34 × 10 5 CFU/g; 1.78 × 10 6 CFU/g vs. 9.03 × 10 7 CFU/g) during the first 18 months of life. Positive maternal atopy history influenced colonization with staphylococci in newborns, anaerobic bacteria, enterococci in 3-month-old infants and anaerobic bacteria in 6-month-old infants. Discussion Our study shows that the gut colonization is a constant process. For the first time, we present the trends in bacterial establishment in a group of more than 170 Polish children. The positive role of breastfeeding in the establishment of gut flora was previously suggested. Unexpectedly, among mostly breastfed children no relation between breastfeeding and the infantile gut microflora was found. Conclusions The intestinal colonization is continuously changed over the first 18 months of life and is influenced by positive maternal atopy history.
- Subjects
POLAND; INTESTINAL diseases; NEONATAL diseases; PUBLIC health; ANAEROBIC bacteria; ATOPY; POPULATION
- Publication
Polish Annals of Medicine, 2017, Vol 24, Issue 2, p138
- ISSN
1230-8013
- Publication type
Article
- DOI
10.1016/j.poamed.2016.06.004