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- Title
Correlation between estrogen receptor alpha expression, collagen content and stiffness in human uterine arteries.
- Authors
Lydrup, Marie-Louise; Fernö, Mårten
- Abstract
<bold>Aim Of the Study: </bold>To investigate the relationship between estrogen receptor alpha expression, collagen content and distensibility of the human uterine artery.<bold>Study Design: </bold>Uterine arteries (n = 13) obtained from women undergoing hysterectomy were mounted for length-tension relations and thereafter frozen for later determination of collagen and estrogen receptor alpha contents.<bold>Results: </bold>A negative correlation between estrogen receptor alpha content and collagen content (r = -0.76, n = 13) and a positive correlation between collagen content and passive tension at 1.4 Lo (r = 0.72, n = 13) in the uterine artery were detected. No difference was found between pre- and postmenopausal women concerning the estrogen receptor alpha content, the collagen content or maximal active force.<bold>Conclusions: </bold>Our data show a functional correlate to the expression of estrogen receptors alpha, as a high content of estrogen receptor alpha correlates with a lower collagen concentration, indicating that estrogen through activation of estrogen receptor alpha protects against vascular collagen accumulation making the vessel more distensible.
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2003, Vol 82, Issue 7, p610
- ISSN
0001-6349
- Publication type
journal article
- DOI
10.1034/j.1600-0412.2003.00209.x