We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Risk of new-onset diabetes after androgen deprivation therapy for prostate cancer in the Asian population 亚洲前列腺癌患者接受雄激素去势治疗后患糖尿病的风险分析
- Authors
Teoh, Jeremy Yuen Chun; Chiu, Peter Ka Fung; Chan, Samson Yun Sang; Poon, Darren Ming Chun; Cheung, Ho ‐ Yuen; Hou, Simon See Ming; Ng, Chi ‐ Fai
- Abstract
Background The associations of androgen deprivation therapy ( ADT) with its adverse events in the Asian population remained largely unknown. We investigated the risk of new-onset diabetes mellitus ( DM) after ADT for prostate cancer in the Asian population. Methods All prostate cancer patients who were treated primarily with radical prostatectomy or radiotherapy, with or without further ADT from 2000 to 2009 were reviewed. Clinical parameters including age, clinical T stage, Gleason score, hypertension, dyslipidemia, impaired fasting glucose, ischemic heart disease, history of stroke, new-onset DM, follow-up duration, form and duration of ADT were reviewed. The risk of DM after ADT was analyzed with Kaplan- Meier method and multivariate Cox regression analysis. Results A total of 388 patients were included, consisting of 169 patients in the non- ADT group and 219 patients in the ADT group. Upon Kaplan- Meier analysis, the ADT group had a higher risk of new-onset DM ( P = 0.011). Upon multivariate Cox regression analysis, dyslipidemia ( HR 2.32, 95% CI 1.07-5.00, P = 0.032), impaired fasting glucose ( HR 5.92, 95% CI 1. 2.27-15.45, P < 0.001) and the use of ADT in the form of GnRH agonist ( HR 3.34, 95% CI 1.19-9.39, P = 0.022) and bilateral orchiectomy ( HR 6.49, 95% CI 1.48-28.55, P = 0.013) were associated with increased risk of new-onset DM. Conclusions There was increased risk of new-onset DM after ADT for prostate cancer in the Asian population. Regular screening of DM can be considered after the initiation of ADT, especially in patients with known history of dyslipidemia and impaired fasting glucose.
- Subjects
ANDROGEN drugs; DIABETES; PROSTATE cancer treatment; PROSTATECTOMY; KAPLAN-Meier estimator; REGRESSION analysis
- Publication
Journal of Diabetes, 2015, Vol 7, Issue 5, p672
- ISSN
1753-0393
- Publication type
Article
- DOI
10.1111/1753-0407.12226