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- Title
Bivalent Vaccine Effectiveness Against Anal Human Papillomavirus Positivity Among Female Sexually Transmitted Infection Clinic Visitors in the Netherlands.
- Authors
Woestenberg, Petra J; King, Audrey J; Benthem, Birgit H B Van; Leussink, Suzan; Sande, Marianne A B Van der; Hoebe, Christian J P A; Bogaards, Johannes A; Services, Medical Microbiological Laboratories and the Public Health; Van Benthem, Birgit H B; Van der Sande, Marianne A B; Medical Microbiological Laboratories and the Public Health Services
- Abstract
Human papillomavirus (HPV) vaccines are indicated for anal cancer prevention, but evidence for vaccine effectiveness (VE) against anal HPV infections among women is limited. We estimated the VE (≥1 dose) against anal HPV positivity of the bivalent vaccine, whose target types HPV-16/18 are associated with approximately 90% of HPV-related anal cancers. Among 548 female STI clinic visitors 16-24 years old who provided an anal swab sample as part of a repeated cross-sectional survey, VE against HPV-16/18 was 89.9% (95% confidence interval, 63.0%-97.2%). Type-specific VE correlated well with VE against cervicovaginal HPV (Spearman ρ = 0.76), suggesting comparable effectiveness of HPV-16/18 vaccination against genital and anal infections.
- Subjects
NETHERLANDS; VACCINE effectiveness; SEXUALLY transmitted diseases; ANAL cancer; PAPILLOMAVIRUSES; ANUS; COMPARATIVE studies; FEMALE reproductive organ diseases; IMMUNITY; IMMUNIZATION; RESEARCH methodology; MEDICAL cooperation; PAPILLOMAVIRUS diseases; RESEARCH; COMBINED vaccines; HUMAN papillomavirus vaccines; EVALUATION research; CROSS-sectional method
- Publication
Journal of Infectious Diseases, 2020, Vol 221, Issue 8, p1280
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiz187