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- Title
Functional significance of post-myocardial infarction inflammation evaluated by <sup>18</sup>F-fluorodeoxyglucose imaging in swine model.
- Authors
Xi, Xiao-Ying; Zhang, Feifei; Wang, Jianfeng; Gao, Wei; Tian, Yi; Xu, Hongyu; Xu, Min; Wang, Yuetao; Yang, Min-Fu
- Abstract
<bold>Background: </bold>The aim of the study was to investigate the relationship between post-myocardial infarction (MI) inflammation and left ventricular (LV) remodeling in a swine model by 18F-fluorodeoxyglucose (FDG) imaging.<bold>Methods: </bold>MI was induced in swine by balloon occlusion of the left anterior descending coronary artery. A series of FDG positron emission tomography (PET) images were taken within 2 weeks post-MI, employing a comprehensive strategy to suppress the physiological uptake of cardiomyocytes. Echocardiography was applied to evaluate LV volume, global and regional function. CD68+ macrophage and glucose transporters (GLUT-1, -3 and -4) were investigated by immunostaining.<bold>Results: </bold>The physiological uptake of myocardium was adequately suppressed in 92.3% of PET scans verified by visual analysis, which was further confirmed by the minimal expression of myocardial GLUT-4. Higher FDG uptake was observed in the infarct than in the remote area and persisted within the observational period of 2 weeks. The FDG uptake of infarcted myocardium on day 1 post-MI was correlated with LV global remodeling, and the FDG uptake of infarcted myocardium on days 1 and 8 post-MI had a trend of correlating with regional remodeling of the infarct area.<bold>Conclusions: </bold>We here report a feasible swine model for investigating post-MI inflammation. FDG signal in the infarct area of swine persisted for a longer duration than has been reported in small animals. FDG activity in the infarct area could predict LV remodeling.
- Subjects
SWINE; INFARCTION; POSITRON emission tomography; GLUCOSE transporters; INFLAMMATION
- Publication
Journal of Nuclear Cardiology, 2020, Vol 27, Issue 2, p519
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1007/s12350-019-01952-0