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- Title
Nanoscale Drug Delivery Systems: A Current Review on the Promising Paclitaxel Formulations for Future Cancer Therapy.
- Authors
Fang, Ru; Yang, Shaozong; Wang, Yanbin; Qian, Hua
- Abstract
Paclitaxel (PTX) is usual for the treatment of a variety of malignancies, however, its applications are greatly limited due to its poor water solubility. Over the past years, there has been a considerable research interest in the area of nanoscale drug delivery systems (DDSs) as carrier for PTX due to their solubilization, safety, targeting and controlled release. There are many different types and shapes of nanoscale DDSs that have been prepared to deliver PTX, including nanoliposome, lipid nanoemulsion, nanosuspension, nanocapsule, nanofiber, nanotube, nanopolymersome, micelle and nanoparticle (NP). Nanoscale DDSs can be based on lipids, proteins, polysaccharides, polymers or other materials. The recent strategic developments of PTX formulation have been discussed with emphasis on lipid-, polymer- and protein-based nanoscale DDSs. Here we focus on the comparative analysis of the preparation, morphology, solubilization, targeting, penetrability, controllability and efficacy profile of various PTX-loaded nanoscale DDSs, which were reported in the different researches. Meanwhile the advantages and disadvantages are also discussed for each type of DDS. Furthermore, the current review embodies an in-depth discussion of human serum albumin (HSA) NP formulation, which showed significantly great efficacy and low toxicity. All the information obtained in this review might shed light on designing new and better nanoscale PTX formulations for potential anticancer applications in the clinic. To realize "effective, safe and controllable", protein nanoparticles are particularly interesting among the available potential nanoscale drug delivery systems for paclitaxel formulations, especially for the self-assembly protein nanoparticles. Self-assembly protein nanoparticle was obtained using two-step method, such as exposure of the internal hydrophobic groups on protein surface and addition of hydrophobic paclitaxel.
- Subjects
CANCER treatment; PACLITAXEL; DRUG delivery systems; EXCIPIENTS; NANOMEDICINE; SOLUBILITY
- Publication
NANO, 2015, Vol 10, Issue 5, p-1
- ISSN
1793-2920
- Publication type
Article
- DOI
10.1142/S1793292015300042