We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Skeletal muscle energetics assessed by <sup>31</sup>P-NMR in prepubertal girls with a familial predisposition to obesity.
- Authors
Treuth, M S; Butte, N F; Herrick, R
- Abstract
OBJECTIVE:: To determine whether skeletal muscle energetics, measured by in vivo 31P-nuclear magnetic resonance spectroscopy during plantar flexion exercise, differ between multiethnic, prepubertal girls with or without a predisposition to obesity. DESIGN:: Cross-sectional study. SUBJECTS:: Girls (mean age and body fat±s.d.=8.6±0.3 y and 22.6±4.2%) were recruited according to parental leanness or obesity defined as follows: LN (n=22), two lean parents, LNOB (n=18), one lean and one obese parent; and OB (n=15), two obese parents. MEASUREMENTS:: A 3 min, rest–exercise–recovery plantar flexion protocol was completed. Work was calculated from the force data. Spectra were analyzed for inorganic intracellular phosphate (Pi), phosphocreatine (PCr), Pi/PCr (ratio of the low and high energy phosphates indicating the bioenergetic state of the cell), intracellular pH, and adenosine triphosphate (ATP). Magnetic resonance imaging was used to determine calf muscle volume. RESULTS:: BMI was lower in the girls in the LN group (15.9±1.5 kg/m2) compared to the OB group (16.7±1.3 kg/m2) of girls (P<0.05), with no difference with the LNOB group (16.7±1.9 kg/m2). Adjusted for muscle volume and cumulative work, no differences in Pi, PCr, Pi/PCr, pH, or ATP were observed among the LN, LNOB and OB groups at rest, the end of exercise, and after 60 and 300 s of recovery. From rest to the end of exercise, Pi and Pi/PCr (mean±s.d.: 0.2±0.1 vs 1.5±1.0) increased, whereas PCr and pH (7.04±0.06 vs 6.95±0.10) decreased (all P<0.001). By 60 s of recovery, Pi and Pi/PCr decreased, whereas PCr and pH increased (all P<0.001). CONCLUSIONS:: Skeletal muscle energetics, specifically Pi/PCr and pH measured during plantar flexion exercise, do not differ between prepubertal girls with or...
- Subjects
EXERCISE; OBESITY; GIRLS
- Publication
International Journal of Obesity & Related Metabolic Disorders, 2001, Vol 25, Issue 9, p1300
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0801666