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- Title
Effect of nitrendipine on histamine release from human basophil leukocytes.
- Authors
Miadonna, A.; Tedeschi, A.; Leggieri, E.; Fabbri, C.; Lorini, M.; Froldi, M.; Zanussi, C.
- Abstract
The effect of the new calcium antagonist nitrendipine on <em>in vitro</em> basophil activation was evaluated in 10 subjects. The histamine release induced by calcium ionophore A23187, f-met peptide and anti-IgE was inhibited, in a dose-dependent fashion, by nitrendipine in the concentration range of 1-100 μM. The activity of this calcium antagonist seems complex and related to an interference with calcium at multiple sites. At concentrations higher than 200 μM, nitrendipine causes histamine release from basophil leukocytes. This histamine secretion is likely to be due to a cytotoxic effect, since it is associated with an increase in LDH levels in the cell supernatant.
- Subjects
NITRENDIPINE; LEUCOCYTES; HISTAMINE; PEPTIDES; CALCIUM; ANTI-immunoglobulin E autoantibodies
- Publication
Allergy, 1987, Vol 42, Issue 4, p298
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/j.1398-9995.1987.tb02213.x