We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Lymphocyte subsets and soluble forms of MIC-A and MIC-B are prognostic factors in non-Hodgkin lymphoma patients.
- Authors
Olivas-Bejarano, Ana Cristina; Montiel-Cervantes, Laura Arcelia; del Carmen Perez-Retiguin, Flor; Garcia-Gutierrez, Socrates; Cruz-Hernandez, Teresita Rocio; Lezama-Palacios, Ruth Angelica; Reyes-Maldonado, Elba; Vela-Ojeda, Jorge
- Abstract
MIC-A and MIC-B are the natural ligands for NKG2D, an activator receptor expressed in NK cells. Soluble isoforms of MIC-A and MIC-B (sMICA, sMICB) have been identified in different malignancies, affecting NK cells' cytotoxicity. The study was performed to determine the levels of sMICA, sMICB, the expression of MIC-A, and MIC-B on tumor tissues, and lymphocyte subpopulations (CD4 + , CD8 + , NK, NKT, Tγδ cells, B cells, monocytes) in 94 patients with non-Hodgkin's lymphoma (NHL) and 72 healthy donors. The most frequent lymphoma was diffuse large B cell lymphoma (48%). Patients with NHL had decreased numbers of CD4 T cells, CD8 T cells, B cells, monocytes, NK cells, type 1 dendritic cells, γδ T cells, and increased iNKT cells. Patients showed higher levels of sMIC-A and similar serum levels of sMIC-B. Survival was poorer in patients having higher LDH values and lower numbers of CD4 T cells, type 1 dendritic cells, gamma-delta T cells, and high levels of sMIC-A. In conclusion, high levels of sMIC and decreased numbers in circulating lymphocyte subsets are related to poor outcomes in NHL.
- Subjects
LYMPHOCYTE subsets; NON-Hodgkin's lymphoma; PROGNOSIS; KILLER cells; B cell lymphoma
- Publication
Annals of Hematology, 2024, Vol 103, Issue 4, p1317
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-023-05583-x