We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
3′CBFB deletion in CBFB-rearranged acute myeloid leukemia retains morphological features associated with inv(16), but patients have higher risk of relapse and may require stem cell transplant.
- Authors
Tang, Guilin; Zou, Ying; Wang, Sa A.; Borthakur, Gautam; Toruner, Gokce; Hu, Shimin; Li, Shaoying; Xu, Jie; Medeiros, L. Jeffrey; Tang, Zhenya
- Abstract
Fluorescence in situ hybridization analysis (FISH) using a CBFB breakapart probe is widely used to detect CBFB rearrangement (CBFBr) in cases of acute myeloid leukemia (AML). However, detection of 3′CBFB deletion (3′CBFBdel) often poses a challenge for interpretation, and the clinical importance of 3′CBFBdel associated CBFBr remains largely unknown. We identified 16 AML patients with 3′CBFBdel, 11 (69%) of which were confirmed to have CBFB::MYH11 fusion. These 11 patients presented with de novo AML; 10 showed myelomonocytic differentiation, 8 had a prominent eosinophilic component, and 7 showed characteristic eosinophils with basophilic granules. Next generation sequencing showed mutations in 7/8 patients, 5 with KRAS/NRAS, 3 with FLT3-TKD, but none with KIT mutations. Except for one patient who died 5 days after diagnosis of AML, all 10 patients received chemotherapy and achieved remission initially. However, within 3 years, 5 (50%) patients had relapsed, of whom, 1 died and 4 received hematopoietic stem cell transplant. After a median follow-up of 76 months, 3 patients died and 8 were alive in complete remission. Our study shows that detection of 3′CBFBdel is not equivalent to unbalanced CBFB rearrangement, and therefore, an alternative confirmatory test is warranted. AML with 3′CBFBdel/CBFBr often shows similar pathological features to AML with inv(16), but appears to have different mutation profiles and a higher risk of relapse requiring hematopoietic stem cell transplant.
- Subjects
STEM cell transplantation; ACUTE myeloid leukemia; HEMATOPOIETIC stem cells; FLUORESCENCE in situ hybridization
- Publication
Annals of Hematology, 2022, Vol 101, Issue 4, p847
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-022-04767-1