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- Title
ASPIRIN VS RIVAROXABAN FOR VENOUS THROMBOEMBOLISM PROPHYLAXIS AFTER HIP OR KNEE ARTHROPLASTY: RANDOMIZED COMPARATIVE STUDY.
- Authors
Kalia, Anchin; Patel, Krunal; Rijhwani, Puneet; Kumar, Sandeep
- Abstract
Background : Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a significant postoperative complication following hip or knee arthroplasty. Effective prophylaxis is essential to prevent these complications, and various anticoagulants, including aspirin and rivaroxaban, are commonly used for this purpose. Despite their widespread use, there is ongoing debate regarding the optimal agent for VTE prophylaxis in this setting. Aim and Objective : This study aimed to compare the efficacy and safety of aspirin versus rivaroxaban in the prevention of VTE after hip or knee arthroplasty. Material and Methods : A randomized, comparative study was conducted at Mahatma Gandhi Medical College & Hospital, Jaipur, from July 2022 to December 2023. A total of 100 patients undergoing elective primary or revision hip or knee arthroplasty were included in the study. Participants received rivaroxaban (10 mg daily) from postoperative day 1 to day 5. Thereafter, they were randomized to continue either aspirin (75 mg daily) or rivaroxaban (10 mg daily) for an additional 9 days (knee arthroplasty) or 30 days (hip arthroplasty). The primary outcome was the incidence of VTE, confirmed by clinical examination and imaging. Secondary outcome included bleeding complications. Results : Both aspirin and rivaroxaban were effective in preventing VTE, with no significant differences between the groups. The suspicion of VTE was similar in both groups, but imaging was normal in all suspected patients. Bleeding complications were also comparable between the two treatment regimens. Conclusion : Aspirin is as effective and safe as rivaroxaban for VTE prophylaxis after hip or knee arthroplasty. Given its cost-effectiveness and similar safety profile, aspirin presents a viable alternative to rivaroxaban for postoperative VTE prophylaxis in these patients.
- Subjects
TOTAL hip replacement; VENOUS thrombosis; THROMBOEMBOLISM; SURGICAL complications; PULMONARY embolism
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 7, p2639
- ISSN
0975-3583
- Publication type
Article