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Updating the Pharmacological Effects of α-Mangostin Compound and Unraveling Its Mechanism of Action: A Computational Study Review.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4723, doi. 10.2147/DDDT.S478388
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- Article
Topical hADSCs-HA Gel Promotes Skin Regeneration and Angiogenesis in Pressure Ulcers by Paracrine Activating PPARβ/δ Pathway.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4799, doi. 10.2147/DDDT.S474628
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- Article
Updating the Pharmacological Effects of α-Mangostin Compound and Unraveling Its Mechanism of Action: A Computational Study Review.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4723, doi. 10.2147/DDDT.S478388
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- Article
Nephroprotective Activity of Angelica keiskei (Miq). Koidz. on Cisplatin-Induced Rats: Reducing Serum Creatinine, Urea Nitrogen, KIM-1, and Suppressing NF-kappaB p65 and COX-2.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4707, doi. 10.2147/DDDT.S481479
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- Article
The Culprit Behind HBV-Infected Hepatocytes: NTCP.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4839, doi. 10.2147/DDDT.S480151
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- Article
Review on Cassia alata Bioactive Compounds: In silico, in vitro, and in vivo Studies.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4427, doi. 10.2147/DDDT.S477679
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- Article
Prediction of Pharmacokinetic Drug–Drug Interactions Involving Anlotinib as a Victim by Using Physiologically Based Pharmacokinetic Modeling.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4585, doi. 10.2147/DDDT.S480402
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- Article
Population Pharmacokinetics of Tigecycline for Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4459, doi. 10.2147/DDDT.S473080
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- Article
Phytochemical Characterization and Synergistic Antibacterial Effects of Colebrookea Oppositifolia Essential Oil as Adjuvants to Modern Antibiotics in Combating Drug Resistance.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4601, doi. 10.2147/DDDT.S489517
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- Article
Oral Bacterial Lysate OM-85: Advances in Pharmacology and Therapeutics.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4387, doi. 10.2147/DDDT.S484897
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- Article
Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4629, doi. 10.2147/DDDT.S483140
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- Article
Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4661, doi. 10.2147/DDDT.S473437
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- Article
Network Pharmacology and Experimental Verification: SanQi-DanShen Treats Coronary Heart Disease by Inhibiting the PI3K/AKT Signaling Pathway.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4529, doi. 10.2147/DDDT.S480248
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- Article
Minimum Local Anesthetic Dose of Ropivacaine in Cesarean Section for Real-Time Ultrasound-Guided Spinal Anesthesia Using 24-Gauge versus 26-Gauge Needles Based on Fluid Simulation Technology: A Randomized Controlled Trial.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4401, doi. 10.2147/DDDT.S476710
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- Article
Sivelestat Sodium Alleviates Ischemia-Reperfusion-Induced Acute Kidney Injury via Suppressing TLR4/Myd88/NF-κB Signaling Pathway in Mice.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4449, doi. 10.2147/DDDT.S480148
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- Article
The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial [Letter].
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4527, doi. 10.2147/DDDT.S497570
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- Article
Apigenin Attenuates Transverse Aortic Constriction-Induced Myocardial Hypertrophy: The Key Role of miR-185-5p/SREBP2-Mediated Autophagy [Letter].
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4705, doi. 10.2147/DDDT.S498092
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- Article
Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4565, doi. 10.2147/DDDT.S479055
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- Article
Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4511, doi. 10.2147/DDDT.S479447
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- Article
Intranasal Dexmedetomidine-Esketamine Combination Premedication versus Monotherapy for Reducing Emergence Delirium and Postoperative Behavioral Changes in Pediatric Tonsillectomy and/or Adenoidectomy: A Randomized Controlled Trial.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4693, doi. 10.2147/DDDT.S488706
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- Article
Integrating Network Pharmacology and Metabolomics to Reveal the Immunomodulatory Mechanism of Ethnomedicine Rodgersia sambucifolia Hemsl.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4749, doi. 10.2147/DDDT.S479341
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- Article
Integrated Metabolomics and Network Pharmacology Study on the Mechanism of Rehmanniae radix Extract for Treating Thrombosis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4859, doi. 10.2147/DDDT.S475838
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- Article
Global Trends in Oliceridine (TRV130) Research from 2013 to 2024: A Bibliometrics and Knowledge Graph Analysis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4681, doi. 10.2147/DDDT.S475205
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- Article
Ginsenoside Rb1 Alleviates DSS-Induced Ulcerative Colitis by Protecting the Intestinal Barrier Through the Signal Network of VDR, PPARγ and NF-κB.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4825, doi. 10.2147/DDDT.S481769
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- Article
Dexmedetomidine and Dexamethasone as Adjuvants to the Local Anesthetic Mixture in Rhomboid Intercostal and Sub-Serratus Block for Video-Assisted Thoracoscopic Surgery: A Randomized, Double-Blind, Controlled Trial.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4485, doi. 10.2147/DDDT.S476929
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- Article
Mesenchymal Stem Cell-Based NK4 Gene Therapy in Nude Mice Bearing Gastric Cancer Xenografts [Corrigendum].
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4481, doi. 10.2147/DDDT.S493671
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- Article
Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4471, doi. 10.2147/DDDT.S466603
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- Article
Comparing Remimazolam and Propofol for Postoperative Anesthesia Satisfaction in Outpatient Gynecological Surgery: A Randomized Clinical Trial.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4615, doi. 10.2147/DDDT.S483029
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- Article
Bu Shen Huo Xue Formula Provides Neuroprotection Against Spinal Cord Injury by Inhibiting Oxidative Stress by Activating the Nrf2 Signaling Pathway.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4779, doi. 10.2147/DDDT.S487307
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- Article
Aqueous Extract of Rhubarb Promotes Hepatotoxicity via Facilitating PKM2-Mediated Aerobic Glycolysis in a Rat Model of Diethylnitrosamine-Induced Liver Cancer.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4497, doi. 10.2147/DDDT.S476273
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- Article
Addition of Dexmedetomidine to the Anesthesia Regimen Attenuates Pain and Improves Early Recovery After Esophageal Endoscopic Submucosal Dissection: A Randomized Controlled Trial.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4551, doi. 10.2147/DDDT.S475749
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- Article
A Comprehensive Review of Coptidis Rhizoma and Magnoliae Officinalis Cortex Drug Pair and Their Chemical Composition, Pharmacological Effects and Pharmacokinetics Analysis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4413, doi. 10.2147/DDDT.S477381
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- Article
Subanesthetic Dose of Esketamine Improves the Sedative and Analgesic Effects of Dexmedetomidine and Remifentanil in Liposuction Anesthesia: A Prospective, Double-Blinded, Randomized Controlled Trial.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 3645, doi. 10.2147/DDDT.S470891
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- Article
Deciphering the Dynamics of EGFR-TKI Resistance in Lung Cancer: Insights from Bibliometric Analysis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4327, doi. 10.2147/DDDT.S478910
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- Article
Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4215, doi. 10.2147/DDDT.S475005
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- Article
Semaglutide Alleviates Ovary Inflammation via the AMPK/SIRT1/NF‑κB Signaling Pathway in Polycystic Ovary Syndrome Mice.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 3925, doi. 10.2147/DDDT.S484531
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- Article
Untargeted Lipidomics Analysis to Discover Lipid Profiles and Biomarkers of Rabbit Acne Model and Reveal Action Mechanism of Isotretinoin.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4003, doi. 10.2147/DDDT.S476649
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- Article
Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 3959, doi. 10.2147/DDDT.S463626
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- Article
Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4241, doi. 10.2147/DDDT.S489458
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- Article
Protective Effect of Fasudil on Testicular Ischemia-Reperfusion Injury in Rats.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4319, doi. 10.2147/DDDT.S480774
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- Article
Effects of Propofol, Low and High Doses of Remimazolam on Hemodynamic and Inflammatory Response in Laparoscopic Surgery [Response to Letter].
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4303, doi. 10.2147/DDDT.S493578
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- Article
Revisiting Niclosamide Formulation Approaches – a Pathway Toward Drug Repositioning.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4153, doi. 10.2147/DDDT.S473178
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- Article
Metformin's Enigma: Bridging Gaps in Research on Potential Benefits & Associated Risks - A Critical Plea for Comprehensive Investigation [Response to Letter].
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4029, doi. 10.2147/DDDT.S491638
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- Article
Research Hotspots in Mitochondria-Related Studies for AKI Treatment: A Bibliometric Study.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4051, doi. 10.2147/DDDT.S473426
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- Article
Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blind, Randomized Controlled Trial [Response to Letter].
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4117, doi. 10.2147/DDDT.S492879
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- Article
Combining Metagenomics, Network Pharmacology and RNA-Seq Strategies to Reveal the Therapeutic Effects and Mechanisms of Qingchang Wenzhong Decoction on Inflammatory Bowel Disease in Mice.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4273, doi. 10.2147/DDDT.S473688
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- Article
Ozone Administration Reduces Myocardial Ischemia Reperfusion Injury in Streptozotocin Induced Diabetes Mellitus Rat Model.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4203, doi. 10.2147/DDDT.S482309
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- Article
New Perspectives on Obesity-Associated Nephropathy from Pathophysiology to Therapeutics: Revealing the Promise of GLP-1 RA Therapy.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4257, doi. 10.2147/DDDT.S476815
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- Article
Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanism of Qushi Huatan Decoction Against Coronary Heart Disease.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4033, doi. 10.2147/DDDT.S463054
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- Article
Identification of Potential Therapeutics for Infantile Hemangioma via in silico Investigation and in vitro Validation.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 4065, doi. 10.2147/DDDT.S460575
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- Article