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- Title
HLA alleles associated to susceptibility to gliptin‐associated bullous pemphigoid in Italian patients.
- Authors
Andreani, Marco; Mariotti, Feliciana; Pira, Anna; Locatelli, Franco; Testa, Giuseppe; Battarra, Mariarosa; Caputi, Priscilla; Scarabello, Alessandra; Bellei, Barbara; Campli, Cristiana Di; Collina, Maria Chiara; Esposito, Ilaria; Giampetruzzi, Anna Rita; Didona, Biagio; Pitocco, Dario; Simone, Clara De; Zenzo, Giovanni Di
- Abstract
Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin‐associated BP (GABP) patients. A significant association between HLA‐DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.
- Subjects
BULLOUS pemphigoid; TYPE 2 diabetes; AUTOIMMUNE diseases; IDIOPATHIC diseases; HAPLOTYPES
- Publication
HLA: Immune Response Genetics, 2024, Vol 104, Issue 2, p1
- ISSN
2059-2302
- Publication type
Article
- DOI
10.1111/tan.15616