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- Title
First Description of a Large Clinical Series of Fetal Alcohol Spectrum Disorders Children and Adolescents in Reunion Island, France.
- Authors
Sennsfelder, Laëtitia; Guilly, Susie; Henkous, Sonia; Lebon, Christophe; Leruste, Sébastien; Beuvain, Pauline; Ferroul, Fanny; Benard, Stéphanie; Payet, Frédérique; Nekaa, Meissa; Bagard, Maité; Lauret, Magaly; Hoareau, Virginie; Caillier, Aurélie; Robin, Stéphanie; Lanneaux, Justine; Etchebarren, Léa; Spodenkiewicz, Michel; Alessandri, Jean-Luc; Morel, Godelieve
- Abstract
Background: Despite several diagnostic guidelines, Fetal Alcohol Spectrum Disorders (FASDs) remain underdiagnosed or misdiagnosed, delaying the care of these patients and support for families. Objective: This study aims to help professionals caring for these children and their families to suspect this diagnosis earlier and to provide the most appropriate follow-up. Methods: A retrospective chart review with monocentric recruitment was performed at the Genetics Unit of the University Hospital of Reunion Island. A total of 147 children and adolescents with FASDs were included. Results: Prenatal alcohol exposure was associated with paternal alcohol consumption in 42.9%, and a high rate of prematurity (33.3%) was observed. Sixty percent of children or adolescents were placed in foster families. Learning difficulties without cognitive deficits were found in 65.8% of cases (50/76). Postural control and fine motor skills disabilities were described, respectively, in 54.7% (35/64) and 72.5% (50/69) of cases. A systematic genetic assessment was carried out, identifying in these FASD patients an associated Copy Number Variation (CNVs) in 22.6% of cases. Conclusion: Children with FASDs combine significant vulnerabilities, associating exposure to alcohol during the preconception and/or the prenatal period, prematurity, complex familial and sociocultural living conditions, and a genetic anomaly in almost a quarter of cases.
- Subjects
FRANCE; PRENATAL exposure delayed effects; MATERNAL exposure; ACADEMIC medical centers; RETROSPECTIVE studies; MOVEMENT disorders; DESCRIPTIVE statistics; FETAL alcohol syndrome; MEDICAL records; ACQUISITION of data; SUBSTANCE abuse in pregnancy; EARLY diagnosis; ALCOHOL drinking; GENETIC mutation; POSTURAL balance; GENETIC testing
- Publication
Children, 2024, Vol 11, Issue 8, p955
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children11080955