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- Title
The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia.
- Authors
Yang, Mengting; Tang, Yanhui; Zhu, Peng; Lu, Haiquan; Wan, Xiaohong; Guo, Qulian; Xiao, Lan; Liu, Chunyan; Guo, Ling; Liu, Wenjun; Yang, You
- Abstract
The E2A-PBX1 gene fusion is a common translocation in B-cell acute lymphoblastic leukaemia. Patients harbouring the E2A-PBX1 fusion gene typically exhibit an intermediate prognosis. Furthermore, minimal residual disease has unsatisfactory prognostic value in E2A-PBX1 B-cell acute lymphoblastic leukaemia. However, the mechanism of E2A-PBX1 in the occurrence and progression of B-cell acute lymphoblastic leukaemia is not well understood. Here, we mainly review the roles of E2A and PBX1 in the differentiation and development of B lymphocytes, the mechanism of E2A-PBX1 gene fusion in B-cell acute lymphoblastic leukaemia, and the potential therapeutic approaches.
- Subjects
LYMPHOBLASTIC leukemia; B cell differentiation; ACUTE leukemia; GENE fusion; PROGNOSIS
- Publication
Annals of Hematology, 2024, Vol 103, Issue 9, p3385
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-023-05595-7