We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Expression of IL-15 and IL-15 Receptor Isoforms in Select Structures of Human Fetal Brain.
- Authors
KUROWSKA, M.; RUDNICKA, W.; MAŚLIŃSKA, D.; MAŚLIŃSKI, W.
- Abstract
A bstract: IL-15, a key cytokine linking innate and acquired immunity, is expressed in many cell types and tissues. Recent data indicate constitutive expression of IL-15 in human neural cell lines and tissues. The aim of the present study was to examine the expression patterns of mRNA encoding IL-15 and IL-15 receptor α (IL-15Rα) isoforms in select structures of human fetal brain. We report that mRNA for IL-15 and IL-15Rα isoforms were expressed in all tested brain structures: cerebral cortex, cerebellum, hippocampus, and thalamus. However, the levels of IL-15 and IL-15Rα mRNA were higher in the hippocampus and cerebellum in comparison with cortex and thalamus. Moreover, higher levels of cytosol in comparison with membrane-bound IL-15 isoform were present in all brain structures. The constitutive, but distinct, expression of IL-15 and its receptors in select human fetal brain structures suggests that IL-15 plays a role in their development and physiology.
- Publication
Annals of the New York Academy of Sciences, 2002, Vol 966, Issue 1, p441
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2002.tb04245.x