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- Title
Lithium Interaction with Flurbiprophen: A Case Report.
- Authors
Aktepe, Evrim; Özkorumak, Evrim; Kandil, Sema
- Abstract
Although lithium continues to be regarded as the treatment of choice for bipolar disorder (BD), the clinical use of this mood stabilizer is associated with a narrow therapeutic range. Relatively minor increases in serum concentrations may induce serious adverse sequelae, and concentrations within therapeutic range may result in toxic reactions. The safety of combining lithium with other medications, therefore, is a major concern. There is conclusive evidence that nonsteroidal anti-inflammatory drugs can increase serum lithium levels, diminish renal lithium clearance, and possibly induce lithium toxicity. We described a patient taking lithium for BD II who presented with lithium toxicity after flurbiprophen was initiated for musculoskeletal complaints.
- Subjects
BIPOLAR disorder; THERAPEUTICS; LITHIUM; AFFECTIVE disorders; MENTAL depression; BLOOD plasma
- Publication
Klinik Psikofarmakoloji Bulteni, 2007, Vol 17, Issue 2, p83
- ISSN
1017-7833
- Publication type
Article