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- Title
Two Neglected Biologic Risk Factors in Bone Grafting and Implantology: High Low-Density Lipoprotein Cholesterol and Low Serum Vitamin D.
- Authors
Choukroun, Joseph; Khoury, Georges; Khoury, Fouad; Russe, Philippe; Testori, Tiziano; Yataro Komiyama; Sammartino, Gilberto; Palacci, Patrick; Tunali, Mustafa; Choukroun, Elisa
- Abstract
Following a failure of a bone graft or an implant placement, the hypothesis of a biological abnormality is rarely considered as a possible cause. A systematic search of peer-reviewed literature for dyslipidemia or vitamin D deficiency may explain this lack of consideration. Excess low-density lipoprotein cholesterol (dyslipidemia) is responsible for a slower bone metabolism or lower dental implant osseointegration. In addition, vitamin D is a key factor for linking innate and adaptive immunity. Both of these factors are compromised under the conditions of vitamin D deficiency. Therefore, vitamin D deficiency slows implant osseointegration and increases the risk of graft infection. Vitamin D is also involved in immune function and therefore allergic reactions.
- Subjects
DENTAL implants; BONE substitutes; DYSLIPIDEMIA; VITAMIN D deficiency; LIPOPROTEINS; OSSEOINTEGRATION
- Publication
Journal of Oral Implantology, 2014, Vol 40, Issue 1, p110
- ISSN
0160-6972
- Publication type
Article
- DOI
10.1563/AAID-JOI-D-13-00062