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- Title
Epilepsy and syphilis: A systematic review and meta-analysis.
- Authors
Chao Zhang; Wei Yue; Shuping Hou; Wanzhen Cui; Lei Xiang; Zhang, Chao; Yue, Wei; Hou, Shuping; Cui, Wanzhen; Xiang, Lei
- Abstract
<bold>Background: </bold>Epileptic seizures were noted as one of the most overlooked manifestations in syphilis; therefore a few clinicians are concerned about the relationship between epilepsy and syphilis. Our study sought to clarify the prevalence and clinical features of epileptic seizures in patients with syphilis.<bold>Methods: </bold>We retrieved relevant articles from different databases, using the keywords "syphilis and epilepsy" and then performed statistical analysis to characterize the relationship between these diseases.<bold>Results: </bold>Forty one articles were included in this study: eight described the prevalence of syphilis and epilepsy and the remaining 33 were case reports on syphilis with epileptic seizures. The meta-analysis included 1252 patients with syphilis. The pooled estimate of proportion of prevalence (95% confidence interval) was 0.1384 (0.0955-0.2005), and the proportion and heterogeneity showed different degrees of change among three subgroups. The systematic review included 46 cases of syphilis with epileptic seizures. Thirty two (80%) patients had motor seizures, among whom 20 (62.5%) had tonic-clonic seizures. In addition, 30 (75%) patients had impaired awareness and 18 (45%) had status seizures. Twenty five (62.5%) patients were 35-55 years of age, and 77.5% of the included patients were men. Thirty seven (97.4%) patients were seizure-free after anti-syphilis treatment.<bold>Limitations: </bold>Research in this field has been conducted for a relatively short period and publication bias may exist. Furthermore, some patients with syphilis and epileptic seizures may not have received a clear diagnosis.<bold>Conclusion: </bold>The proportion of prevalence was 0.1384. Most of the included patients were 35-55 years of age and had impaired awareness and motor seizures. Many patients with syphilis and epileptic seizure showed full recovery or the development of minor neurological sequelae, and nearly all patients were seizure-free after timely anti-syphilis treatment.
- Subjects
EPILEPSY; SYPHILIS; SEIZURES (Medicine); MEDICAL personnel; PEOPLE with epilepsy; DIAGNOSIS; PUBLICATION bias; SYPHILIS complications; DIAGNOSIS of syphilis; RESEARCH; META-analysis; RESEARCH methodology; SYSTEMATIC reviews; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies
- Publication
Indian Journal of Dermatology, Venereology & Leprology, 2021, Vol 87, Issue 4, p483
- ISSN
0378-6323
- Publication type
journal article
- DOI
10.25259/IJDVL_681_19