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- Title
Zinc supplementation ameliorates sorafenib-induced cognitive impairment through ROS/JNK signaling pathway.
- Authors
Zhou, Can-Can; He, Yu-Qiong; Qiu, Yu-Shuang; Ni, Chen-Xu; Shen, Fu-Ming; Li, Dong-Jie
- Abstract
Sorafenib, a multiple kinase inhibitor, is widely used in cancer patients. Recently, clinical studies highlighted the relationship between cognitive deficits and sorafenib exposure. Zinc abundant in the body has been reported to exert neuroprotective activities. However, the effects of zinc supplementation on sorafenib-induced cognitive impairment are still unknown. In the current study, we verified that mice challenged with sorafenib displayed characteristic features of cognitive impairment. However, zinc treatment effectively improved these changes. Histopathological staining also showed that zinc significantly alleviated hippocampal microstructural and ultrastructural damages induced by sorafenib. Meanwhile, zinc significantly reduced sorafenib-induced ROS production and neuronal cells apoptosis in vivo and vitro. Additionally, we also investigated whether zinc protected against sorafenib-induced neuronal cells apoptosis via ROS/JNK pathway through treating SH-SY5Y cells with the NAC or the specific JNK activator anisomycin. The results indicated that NAC performed the same protective effects as zinc in sorafenib-challenged SH-SY5Y cells and activation of JNK by anisomycin partly abolished the protective effects of zinc. Collectively, the present study suggested that inhibition of oxidative stress and the JNK pathway might contribute to the protective effects of zinc against sorafenib-caused cognitive impairment in vivo and vitro.
- Subjects
COGNITION disorders; ZINC; CELLULAR signal transduction; DIETARY supplements; KINASE inhibitors
- Publication
Biological Trace Element Research, 2023, Vol 201, Issue 1, p324
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-022-03142-5