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- Title
The effect of Dunaliella tertiolecta supplementation on diet-induced obesity in UCP1-deficient mice.
- Authors
Yukari Yamashita; Tamaki Takeuchi; Yuki Endo; Ayumi Goto; Misa Uno; Setsuko Sakaki; Yuji Yamaguchi; Hiroyuki Takenaka; Hitoshi Yamashita
- Abstract
We previously demonstrated that dietary supplementation with Dunaliella tertiolecta (DT) increases uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) and improves diet-induced obesity (DIO) in C57BL/6 J mice at thermoneutrality (30 °C). Here, we investigated whether DT improves DIO in a thermoneutral UCP1-deficient (KO) animal. KO mice were fed a high-fat diet supplemented with DT for 12 weeks. Compared to control group without DT, body weight was significantly reduced in DT group with no difference in food intake. Dunaliella tertiolecta -supplemented mice exhibited lower adiposity and well-maintained multilocular morphology in BAT, in which a significant increase in gene expression of PR domain containing 16 was detected in DT group compared to control group. Moreover, increase in UCP2 level and/or decrease in ribosomal protein S6 phosphorylation were detected in adipose tissues of DT group relative to control group. These results suggest that DT supplementation improves DIO by stimulating UCP1-independent energy dissipation at thermoneutrality.
- Subjects
MICE; KNOCKOUT mice; DUNALIELLA; BROWN adipose tissue; UNCOUPLING proteins; DIETARY supplements; ADIPOSE tissues
- Publication
Bioscience, Biotechnology & Biochemistry, 2024, Vol 88, Issue 1, p16
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1093/bbb/zbad138