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- Title
Effects of a pyroglutamyl pentapeptide isolated from fermented barley extract on atopic dermatitis-like skin lesions in hairless mouse.
- Authors
Maruoka, Naruyuki; Watanabe, Bunta; Ando, Daigo; Miyashita, Masahiro; Kurihara, Tatsuo; Hokazono, Hideki
- Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritic and eczematous skin lesions. The skin of AD patients is generally in a dried condition. Therefore, it is important for AD patients to manage skin moisturization. In this study, we examined the effects of orally administered fermented barley extract P (FBEP), which is prepared from a supernatant of barley shochu distillery by-product, on stratum corneum (SC) hydration and transepidermal water loss (TEWL) in AD-like lesions induced in hairless mice using 2,4,6-trinitrochlorobenzene. Oral administration of FBEP increased SC hydration and decreased TEWL in the dorsal skin of this mouse model. Further fractionation of FBEP showed that a pyroglutamyl pentapeptide, pEQPFP comprising all -L-form amino acids, is responsible for these activities. These results suggested that this pyroglutamyl pentapeptide may serve as a modality for the treatment of AD. A novel pyroglutamyl pentapeptide was isolated from FBE. Oral administration of the peptide improved epidermal barrier of AD-like hairless mice.
- Subjects
DERMATOPHAGOIDES; DISTILLERY by-products; ATOPIC dermatitis; SKIN; MICE
- Publication
Bioscience, Biotechnology & Biochemistry, 2020, Vol 84, Issue 8, p1696
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2020.1762480