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- Title
Epidermal growth factor receptor expression in feline oral squamous cell carcinomas.
- Authors
Looper, J. S.; Malarkey, D. E.; Ruslander, D.; Proulx, D.; Thrall, D. E.
- Abstract
Feline oral squamous cell carcinomas (SCC) have a poor prognosis despite aggressive treatment with surgery, radiation and anticancer drugs. Overexpression of the epidermal growth factor receptor (EGFR), a membrane-bound tyrosine kinase receptor, has been found in many human epithelial neoplasms, including oral SCC. EGFR overexpression has been associated with advanced disease and a poor prognosis. The purpose of this study was to determine whether feline oral SCC express EGFR. Thirteen formalin-fixed paraffin wax-embedded biopsy samples from feline oral SCC were analysed for EGFR expression using immunohistochemistry. Nine of 13 tumours (69%) were positive for EGFR expression, suggesting that altered EGFR expression plays a role in feline oral SCC and provides a rationale for a potential clinical benefit using EGFR inhibitors in combination with conventional treatments.
- Subjects
TUMORS in animals; CATS; SQUAMOUS cell carcinoma; CANCER prognosis; EPIDERMAL growth factor; VETERINARY oncology; IMMUNOHISTOCHEMISTRY
- Publication
Veterinary & Comparative Oncology, 2006, Vol 4, Issue 1, p33
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5810.2006.00091.x