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- Title
Development and Application of a Sensor Based on Carbonaceous Materials and Cobalt Phthalocyanine Composite for Electrochemical Determination of Uric Acid.
- Authors
de Fátima Giarola, Juliana; César Pereira, Arnaldo
- Abstract
In the present paper a voltammetric sensor based on glassy carbon electrode (GCE) and cobalt phthalocyanine (CoPc)/multiwalled carbon nanotube (MWCNT) composite has been successfully prepared for uric acid (UA) determination in real samples. The electrochemical behavior of UA at the GCE-CoPc/MWCNT has been evaluated by employing cyclic voltammetry. The charge transfer coefficient, α, and the charge transfer rate constant, κs, for electron transfer between CoPc/MWCNT and GCE were calculated as 0.49 and 19.5±0.51 s−1, respectively. Under optimized conditions (pH 7.0 in 0.10 mol L−1 phosphate buffer) the best technique was the square wave voltammetry and responds linearly to UA from 0.2 up to 1.0 mmol L−1 (r=0.997) and 1.25 up to 4.0 mmol L−1 (r=0.991) with limits of detection and quantification of 0.26 and 0.86 mmol L−1, respectively. The developed method was successfully applied for UA determination in real samples of human urine. The modified electrode exhibits sensitive and stable responses and does not show interferences in presence of dopamine and ascorbic acid.
- Subjects
ELECTROCHEMICAL analysis; PHTHALOCYANINES; CARBON nanotubes; URINE; URIC acid; CARBON electrodes
- Publication
Electroanalysis, 2016, Vol 28, Issue 6, p1348
- ISSN
1040-0397
- Publication type
Article
- DOI
10.1002/elan.201501032