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- Title
Biocatalytic Synthesis of Chiral N‐Functionalized Amino Acids.
- Authors
Hyslop, Julia F.; Lovelock, Sarah L.; Sutton, Peter W.; Brown, Kristin K.; Watson, Allan J. B.; Roiban, Gheorghe‐doru
- Abstract
N‐Functionalized amino acids are important building blocks for the preparation of diverse bioactive molecules, including peptides. The development of sustainable manufacturing routes to chiral N‐alkylated amino acids remains a significant challenge in the pharmaceutical and fine‐chemical industries. Herein we report the discovery of a structurally diverse panel of biocatalysts which catalyze the asymmetric synthesis of N‐alkyl amino acids through the reductive coupling of ketones and amines. Reactions have been performed on a gram scale to yield optically pure N‐alkyl‐functionalized products in high yields.
- Subjects
AMINO acid synthesis; BIOACTIVE compounds; PHARMACEUTICAL industry; CHEMICAL synergy; CHEMICAL affinity
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 42, p14017
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201806893