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- Title
Gold‐Catalyzed C–S Aryl‐Group Transfer in Zinc Finger Proteins.
- Authors
de Paiva, Raphael E. F.; Du, Zhifeng; Nakahata, Douglas H.; Lima, Frederico A.; Corbi, Pedro P.; Farrell, Nicholas P.
- Abstract
Abstract: Reaction of the Au–C N chelate [Au(bnpy)Cl2] with the full‐length zinc finger (ZnF; ZnCys3His) of HIV nucleocapsid protein NCp7 results in C–S aryl transfer from the AuIII organometallic species to a cysteine of the ZnF. The reaction is general and occurs even for finger 3 of the transcription factor Sp1, containing a ZnCys2His2 coordination sphere. This reaction is the first demonstration of group transfer from a coordination compound to biologically important zinc fingers, and is especially noteworthy for the ZnCys2His2 transcription factors. The work expands the corpus of organometallic species which can efficiently modify biomolecules through C‐atom transfer. The electronic features of the gold compound leading to this unexpected reaction were explored by X‐ray absorption spectroscopy.
- Subjects
GOLD catalysts; ARYL group; ZINC-finger proteins; NUCLEOCAPSID structure; MOLECULAR structure of viral capsids; ORGANOMETALLIC compounds
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 30, p9449
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201803082