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- Title
DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization.
- Authors
Reile, Indrek; Aspers, Ruud L. E. G.; Tyburn, Jean ‐ Max; Kempf, James G.; Feiters, Martin C.; Rutjes, Floris P. J. T.; Tessari, Marco
- Abstract
DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes' diffusion coefficients. It has found use in correlating NMR signals and estimating the number of components in mixtures. Applications of DOSY in dilute mixtures are, however, held back by excessively long measurement times. We demonstrate herein, how the enhanced NMR sensitivity provided by SABRE hyperpolarization allows DOSY analysis of low-micromolar mixtures, thus reducing the concentration requirements by at least 100-fold.
- Subjects
AMPLIFICATION reactions; MIXTURES; SPECTROMETRY; NUCLEAR magnetic resonance; DIFFUSION coefficients
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 31, p9302
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201703577