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- Title
Enantioselective Borylation of Aromatic C−H Bonds with Chiral Dinitrogen Ligands.
- Authors
Su, Bo; Zhou, Tai ‐ Gang; Xu, Pei ‐ Lin; Shi, Zhang ‐ Jie; Hartwig, John F.
- Abstract
The borylation of C−H bonds catalyzed by transition metals has been investigated extensively in the past two decades, but no iridium-catalyzed enantioselective borylation of C−H bonds has been reported. We report a set of iridium-catalyzed enantioselective borylations of aromatic C−H bonds. This reaction relies on a set of newly developed chiral quinolyl oxazoline ligands. This process proceeds under mild conditions with good to excellent enantioselectivity, and the borylated products can be converted to enantioenriched derivatives containing new C−O, C−C, C−Cl, or C−Br bonds.
- Subjects
BORYLATION; CHEMICAL reactions; LIGAND exchange reactions; IRIDIUM; OXAZOLINE
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 25, p7311
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201702628