We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Nanotexaphyrin: One-Pot Synthesis of a Manganese Texaphyrin-Phospholipid Nanoparticle for Magnetic Resonance Imaging.
- Authors
Keca, Joseph M.; Chen, Juan; Overchuk, Marta; Muhanna, Nidal; MacLaughlin, Christina M.; Jin, Cheng S.; Foltz, Warren D.; Irish, Jonathan C.; Zheng, Gang
- Abstract
The discovery and synthesis of novel multifunctional organic building blocks for nanoparticles is challenging. Texaphyrin macrocycles are capable and multifunctional chelators. However, they remain elusive as building blocks for nanoparticles because of the difficulty associated with synthesis of texaphyrin constructs capable of self-assembly. A novel manganese (Mn)-texaphyrin-phospholipid building block is described, along with its one-pot synthesis and self-assembly into a Mn-nanotexaphyrin. This nanoparticle possesses strong resilience to manganese dissociation, structural stability, in vivo bio-safety, and structure-dependent T1 and T2 relaxivities. Magnetic resonance imaging (MRI) contrast enhanced visualization of lymphatic drainage is demonstrated with respect to proximal lymph nodes on the head and neck VX-2 tumors of a rabbit. Synthesis of 17 additional metallo-texaphyrin building blocks suggests that this novel one-pot synthetic procedure for nanotexaphyrins may lead to a wide range of applications in the field of nanomedicines.
- Subjects
PHOSPHOLIPIDS; CARDIOLIPIN; ANTIGENS; MACROCYCLIC compounds; MAGNETIC resonance imaging
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 21, p6295
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201600234