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- Title
Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells.
- Authors
Ying Zhang; Li-Juan Fu; Jin-Xia Li; Xiao-Gai Yang
- Abstract
Abstract The effect of gadolinium chloride (Gd) on the proliferation of HeLa cells was investigated at lower concentration. The results obtained by MTT and cell cycle analysis showed that Gd promoted proliferation by inducing S phase entry in HeLa cells at the concentration less than 100 μM. It was further evidenced by both an increase in the levels of phosphorylation of retinoblastoma protein (pRb) and a remarkable increase in cyclin E expression. Moreover, the survival of cells, exposed to Gd up to 3–5 days, was increased compared with control. The attenuation of the serum deprivation-induced cell loss by Gd was associated with the sustained activation of FAK (PY397) and the delayed activation of JNKs pathway. Besides, it appeared that Gd promoted cell proliferation and survival in HeLa cells was not contributed to the ROS generation. Based on the present results, both positive and negative effects of the lanthanides as potential drugs or diagnostic agents are discussed.
- Subjects
GADOLINIUM; HELA cells; PHOSPHORYLATION; RESEARCH; THERAPEUTICS
- Publication
BioMetals, 2009, Vol 22, Issue 3, p511
- ISSN
0966-0844
- Publication type
Article
- DOI
10.1007/s10534-009-9208-5