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- Title
Lack of association between joint hyperlaxity and, I: panic disorder, and II: reactivity to carbon dioxide in healthy volunteers.
- Authors
Benjamin, Jonathan; Ben-Zion, Itzhak Z; Dannon, Pinhas; Schreiber, Shaul; Meiri, Gal; Ofek, Andre; Palatnik, Alex
- Abstract
This study attempted to replicate previous reports of associations between panic disorder and joint hyperlaxity. The authors also examined possible associations between reacitivity to carbon dioxide (CO[sub 2] ), a model for panic vulnerability, and hyperlaxity in healthy volunteers. One hundred and one patients with DSM-IV panic disorder and 39 healthy volunteers were assessed for hyperlaxity by Beighton's criteria. Healthy volunteers also received two vital capacity inhalations of CO[sub 2] . Thirteen (13%) patients had five or more hyperlax joints. This rate did not differ from that in the healthy volunteers. Anxiety in healthy volunteers, as measured by the NIMH self-rating scale, DSM-IV panic symptom scores, and 100 mm visual analog scales of anxiety, increased after CO[sub 2] from a mean of 1.8 to 2.8 (not significant); from 0.5 to 4 ( p < 0.001) and from 8.7 to 11.6 mm ( p < 0.1), respectively. There were no associations between responses to CO[sub 2] and hyperlaxity. Copyright © 2001 John Wiley & Sons, Ltd.
- Subjects
PANIC disorders; DRUG interactions; CARBON dioxide; JOINT hypermobility; PSYCHOPHARMACOLOGY
- Publication
Human Psychopharmacology: Clinical & Experimental, 2001, Vol 16, Issue 2, p189
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.234