We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Metabolic Health and Disease: A Role of Osteokines?
- Authors
Shimonty, Anika; Bonewald, Lynda F.; Huot, Joshua R.
- Abstract
Maintenance of skeletal health is tightly regulated by osteocytes, osteoblasts, and osteoclasts via coordinated secretion of bone-derived factors, termed osteokines. Disruption of this coordinated process due to aging and metabolic disease promotes loss of bone mass and increased risk of fracture. Indeed, growing evidence demonstrates that metabolic diseases, including type 2 diabetes, liver disease and cancer are accompanied by bone loss and altered osteokine levels. With the persistent prevalence of cancer and the growing epidemic of metabolic disorders, investigations into the role of inter-tissue communication during disease progression are on the rise. While osteokines are imperative for bone homeostasis, work from us and others have identified that osteokines possess endocrine functions, exerting effects on distant tissues including skeletal muscle and liver. In this review we first discuss the prevalence of bone loss and osteokine alterations in patients with type 2 diabetes, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cirrhosis, and cancer. We then discuss the effects of osteokines in mediating skeletal muscle and liver homeostasis, including RANKL, sclerostin, osteocalcin, FGF23, PGE2, TGF-β, BMPs, IGF-1 and PTHrP. To better understand how inter-tissue communication contributes to disease progression, it is essential that we include the bone secretome and the systemic roles of osteokines.
- Subjects
METABOLIC disorders; NON-alcoholic fatty liver disease; HOMEOSTASIS; TYPE 2 diabetes; SKELETAL muscle; ENDOCRINE system; LIVER diseases; DISEASE progression
- Publication
Calcified Tissue International, 2023, Vol 113, Issue 1, p21
- ISSN
0171-967X
- Publication type
Article
- DOI
10.1007/s00223-023-01093-0