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- Title
A systematic review of bisphosphonate osteonecrosis (BON) in cancer.
- Authors
Migliorati CA; Woo SB; Hewson I; Barasch A; Elting LS; Spijkervet FK; Brennan MT; Bisphosphonate Osteonecrosis Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO); Migliorati, Cesar Augusto; Woo, Sook-Bin; Hewson, Ian; Barasch, Andrei; Elting, Linda S; Spijkervet, Fred K L; Brennan, Michael T
- Abstract
<bold>Purpose: </bold>This systematic review aims to examine the prevalence of bisphosphonate osteonecrosis (BON) in the cancer population, prevention and treatment protocols, and quality of life issues.<bold>Methods: </bold>A search of MEDLINE/PubMed and EMBASE form October 2003 to December 31, 2008 was conducted with the objective of identifying publications that contained original data regarding BON.<bold>Results: </bold>A total of 28 publications fulfilled inclusion criteria, but only 22 were used for prevalence analysis. No randomized controlled clinical trials, meta-analysis, or quality of life papers were found that contained information regarding either prevalence or treatment protocols for the management of BON. The overall weighted prevalence of BON included a sample of 39,124 patients with a mean weighted prevalence of 6.1%. The weighted prevalence was 13.3% for studies with documented follow-up with a sample size of 927 individuals. The weighted prevalence in studies with undocumented follow-up was 0.7% in a sample of 8,829 chart reviews. Epidemiological studies evaluated a total of 29,368 individual records, and the weighted BON prevalence was 1.2%.<bold>Conclusions: </bold>High-quality studies are needed to accurately characterize the prevalence of BON, and to determine effective treatment protocols.
- Publication
Supportive Care in Cancer, 2010, Vol 18, Issue 8, p1099
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-010-0882-1